Reprotrain

Reproductive Biology Early Research Training

PhD level (Early Stage Researcher)

Filled
PhD level (ESR)
Project Number: 
1
Goal: (i) To identify the sperm nuclear proteome core proteins common to human, mouse and D. melanogaster, (ii) to characterise novel proteins using immuno-cytochemistry and (iii) to search for abnormal relative abundance of proteins in infertile patients
October 2012 - September 2015
Filled
PhD level (ESR)
Project Number: 
6
(i) To identify new chromosomal proteins, perform a transcriptome profiling of distinct spermatid stages and to identify the degree of conservation between mammals and Drosophila. (ii) To identify the function of the newly identified proteins.
October 2012 - September 2015
Filled
PhD level (ESR)
Project Number: 
7
(i) Characterise DNA sequences bound to spermatozoal histones and protamines of fertile (hyaluronan) and subfertile (non-hyaluronan) binding sub-populations of animal sperm using high resolution whole genome microarrays and / or next generation DNA sequencing. (ii) Localise histones and histone bound DNA in sperm from these animals, including human
October 2012 - September 2015
Filled
PhD level (ESR)
Project Number: 
8
(i) To detect and analyse changes in gene expression associated with an infertile versus a fertile phenotype. (ii) To evaluate the utility of semen sampling in the early detection of prostate cancer and prostatic hyperplasia.
October 2012 - September 2015
Filled
PhD level (ESR)
Project Number: 
9
The primary goal of this doctoral thesis will be to characterise the DNA fragmentation and DNA adducts of sperm from infertile patients and relate these to chromatin classification and assisted conception outcomes.
October 2012 - September 2015
Filled
PhD level (ESR)
Project Number: 
4
This ESR's goal will be to characterize the histoneacetyl-transferase(s) and complex(es) responsible for triggering and regulatingthe genome-wide histone hyperacetylation wave preceding the post-meiotic re-organisationof the male genome.
December 2012 - November 2015
Filled
PhD level (ESR)
Project Number: 
5
The aim of ESR4’s work will be to characterize the causes and consequences of region-specific alterations in epigenetic marks of the male genome during spermiogenesis, and examine the mechanisms responsible for maintaining the male specific epigenetic patterns, as well as the post-fertilization consequences of these abnormalities after ICSI.
December 2012 - November 2015
Filled
PhD level (ESR)
Project Number: 
10
i) to identify X-chromosome linked Copy Number Variations (CNVs); ii) to identify new X-linked spermatogenesis candidate genes; iii) to extend the X-linked analysis to the whole genome.
January 2013 - December 2015
Filled
PhD level (ESR)
Project Number: 
11
1) to evaluate the effect of AZFc gene dosage variation on sperm mRNA expression pattern; 2) to evaluate the role of gr/gr deletion as pre-mutation for complete AZFc deletion; 3) to evaluate the role of AZF duplications; 4) to study the relationship between AZF deletions and PAR-linked CNVs.
January 2013 - December 2015
Filled
PhD level (ESR)
Project Number: 
3
To unravel the role of the ubiquitin-conjugating DNA repair enzyme HR6B, and of additional selected proteins in meiotic and postmeiotic chromatin remodeling
September 2013 - November 2015

Post-doc level (Experienced Researcher)

Filled
Post-doc level (ER)
Project Number: 
14
To confirm that prostate cancer can be non-invasively detected in the semen of men without other symptoms.
October 2012 - June 2014
Filled
Post-doc level (ER)
Project Number: 
12
Developing nucleic acid tools and antibodies to adapt them to a number of different assays targeting male infertility and a subset of testis cancer patients. Validation of the biomarkers in a cohort of patient samples prior to possible clinical trials.
June 2013 - April 2015
Filled
Post-doc level (ER)
Project Number: 
13
Identification and validation of pharmacological targets for epigenetic modulators particularly focused on both regulatory events histone acetylation-deacetylation and methylation-demethylation.
October 2013 - August 2015
Filled
Post-doc level (ER)
Project Number: 
2
(i) To identify the function and epigenetic potential of the sperm nuclear proteins identified in collaboration with ESR1. (ii) To determine the differential distribution of the proteins in the nucleohistone and nucleoprotamine domains.
November 2013 - September 2015